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After US approval, Japan OKs Leqembi, its first Alzheimer’s drug, developed by Eisai and Biogen

Published Sat, 01 Feb 2025 00:00:40 GMT

TOKYO (AP) — Japan’s health ministry has approved Leqembi, a drug for Alzheimer’s disease that was jointly developed by Japanese and U.S. pharmaceutical companies. It’s the first drug for treatment of the disease in a country with a rapidly aging population.Developed by Japanese drugmaker Eisai Co. and U.S. biotechnology firm Biogen Inc., the drug’s approval in Japan comes two months after it was endorsed by the U.S. Food and Drug Administration. Leqembi is for patients with mild dementia and other symptoms in the early stages of Alzheimer’s disease, and the first medicine that can modestly slow their cognitive decline.Prime Minister Fumio Kishida, who announced Japan’s approval of Leqembi on Monday, called it “a breakthrough” and said that the “treatment of dementia has now entered a new era.”Kishida has pledged to step up support for the growing number of dementia patients and their families and is due to launch a panel this week to discuss measures f...

Prominent Thai human rights lawyer accused of insulting the king receives a 4-year prison term

Published Sat, 01 Feb 2025 00:00:40 GMT

BANGKOK (AP) — A prominent Thai human rights lawyer was convicted on Tuesday of insulting the monarchy and sentenced to four years in prison, the first conviction under a controversial law guarding the royal institution since a civilian government took office after years of military-backed rule.Arnon Nampa was found guilty of defaming King Maha Vajiralongkorn during a student-led rally on Oct. 14, 2020, that commemorated a popular uprising in 1973 that led to the fall of a decade-long military dictatorship. He was also fined 20,000 baht ($550) for violating an emergency decree banning large public gatherings during the coronavirus pandemic.Arnon, 39, still faces 13 more cases under the lese majeste law, which makes insulting the monarch, his immediate family and the regent punishable by up to 15 years in prison.The court said in its ruling Tuesday that Arnon had declared at the rally that if it were dispersed, it would be at the order of King Maha Vajiralongkon. It said that stateme...

NextGenerationEU: Commission endorses Portugal's €22.2 billion modified recovery and resilience plan, including a REPowerEU chapter

Published Sat, 01 Feb 2025 00:00:40 GMT

The European Commission has given a positive assessment of Portugal's modified recovery and resilience plan, which includes a REPowerEU chapter. The plan is now worth €22.2 billion in grants and loans and covers 44 reforms and 117 investments.Portugal's REPowerEU chapter consists of 6 reforms and 16 investments to deliver on the REPowerEU Plan's objectives to make Europe independent from Russian fossil fuels well before 2030. These measures focus on energy efficiency in buildings, support to green industry, renewables and renewable gases, sustainable transport and the electricity grid.In addition to this, Portugal has also proposed 34 new or scaled up investments to its original plan and five new reforms. The proposed reforms aim to enhance the efficiency of both the social protection system and the tax system, promote circular economy and waste management, and further boost the digital transition of the public administration. No investment or reform has been removed from the initia...

SF Giants ace dismisses Cy Young talk, wants wins and ‘big changes’ instead

Published Sat, 01 Feb 2025 00:00:40 GMT

SAN FRANCISCO – San Francisco Giants starting pitcher Logan Webb believes Blake Snell should win the National League Cy Young Award this year.Why is that, Webb was asked.“Because he has a 2.30 (ERA), a 2.20, whatever it is,” Webb said of the San Diego Padres’ left-hander. “That’s pretty good.”Snell now has an MLB-leading 2.25 ERA after his exceptional performance Monday against the Giants, as he struck out seven over six scoreless innings. He’s also fourth with 234 strikeouts and has a solid 14-9 record for a Padres team that’s been well out of the playoff picture almost all season.But Webb outshined Snell in a terrific pitcher’s duel at Oracle Park and a rare highlight for the Giants this month. In the second complete game of his career, with both coming this season, Webb allowed nine hits but struck out seven as he gave the Giants a chance to come back and earn a 2-1 win, keeping their faint playoff hopes alive for at least another day.“It’s kind of hard trying to go pitch f...

Olympic doping case of Russian figure skater Kamila Valieva opens Tuesday in Swiss sports court

Published Sat, 01 Feb 2025 00:00:40 GMT

The doping case of teenage Russian figure skater Kamila Valieva that shocked the 2022 Beijing Olympics returns to the highest court in sports on Tuesday.The Court of Arbitration for Sport begins a hearing set for at least three days with Valieva, now aged 17, expected to testify by video link from Russia in a case that was slow-walked in her home country and could now deliver a verdict by the end of the year.Awaiting the outcome are nine American skaters who could become Olympic champions in the team event after finishing second in Beijing behind the Russians and their star performer Valieva. The center of Valieva’s defense has been that her positive test for a heart medication banned in sports was caused by accidental contamination – maybe from a glass or plate – by tablets her grandfather claimed he took.Valieva and her legal team “intend to conduct further investigation and present the results” at future hearings in the case, the first Russian anti-doping tribunal to judge the ca...

Powerball: el premio mayor sube a US$ 835 millones y estos son los números ganadores del 25 de septiembre

Published Sat, 01 Feb 2025 00:00:40 GMT

(CNN) — Una vez más, el sorteo de Powerball de este lunes por la noche no produjo ningún ganador del gran premio, ya que el premio mayor continúa aumentando.La Asociación de Lotería Multiestatal dijo que el premio mayor estimado para el próximo sorteo de este miércoles es de US$ 835 millones. Ese será el segundo premio mayor más grande de Powerball para 2023.El gran premio del sorteo de este lunes fue de US$ 793,6 millones. Hubo cuatro ganadores millonarios que acertaron todas las bolas blancas sin acertar el Powerball, tres de los cuales compraron sus boletos en Florida. El último sorteo que produjo un ganador del gran premio fue el 19 de julio.Los números ganadores de este lunes fueron 10-12-22-36-50, con un Powerball de 4.The-CNN-Wire™ & © 2023 Cable News Network, Inc., a Warner Bros. Discovery Company. All rights reserved.Source

Rangers back Gray with 3 straight homers, beat Angels 5-1 to maintain AL West lead

Published Sat, 01 Feb 2025 00:00:40 GMT

ANAHEIM, Calif. (AP) — Adolis García, Mitch Garver and Nathaniel Lowe hit consecutive home runs in the sixth inning, and the first-place Texas Rangers beat the Los Angeles Angels 5-1 on Monday night for their sixth straight victory.Texas maintained its 2 1/2-game lead in the AL West over Houston, which won 5-1 at Seattle to drop the skidding Mariners four games behind the Rangers with six to play.“We were pretty quiet there through the first five innings and García woke us up there with his home run,″ Texas manager Bruce Bochy said. “We came alive and it was good to see the long ball.″Marcus Semien also launched a solo homer for Texas, and Jon Gray (9-8) pitched six strong innings for his first win since Aug. 11. He had lasted fewer than four innings in three straight starts. “He looked great and threw the ball really well,″ Bochy said. “He threw the one pitch that got away from him for the home run, but I just like the way he regrouped. He looked so focused out there tonight.″One d...

¿Avanza la lucha de Bruce Willis contra la demencia? Su esposa lo revela

Published Sat, 01 Feb 2025 00:00:40 GMT

La esposa de Bruce Willis, Emma Heming Willis, se sincera sobre las dificultades de la batalla por la salud de su marido.A principios de este año, la familia de Willis anunció su diagnóstico de demencia frontotemporal, una condición que puede causar dificultades en la comunicación. Y como compartió recientemente Heming, que tiene a sus hijos Mabel, de 11 años, y Evelyn, de 9, con la estrella de “Duro de matar”, su viaje hacia la salud ha sido difícil.“Lo que estoy aprendiendo es que la demencia es difícil”, dijo durante el episodio del 25 de septiembre de TODAY. “Es duro para la persona diagnosticada, y también es duro para la familia. Y eso no es diferente para Bruce, ni para mí, ni para nuestras hijas. Cuando dicen que se trata de una enfermedad familiar, realmente lo es”.Como explicó Heming, conocer los detalles del estado de salud del actor “fue la bendición y la maldición”.“Entender finalmente lo que estaba sucediendo, para ...

Prince George’s Film Festival returns for ‘Take Two’ with local filmmakers and star-studded panels

Published Sat, 01 Feb 2025 00:00:40 GMT

toggle audio on and off change volume download audio WTOP's Jason Fraley previews the Prince George's Film Festival (Part 1) $(function () { $('.wtop-audio-container .fa-play').on('click', function(){ var audio_filename = $('div.wtop-audio-file').data("mp3-url"); ga('send', 'event', 'Audio', 'play', audio_filename); }); }); The inaugural event was such a success last year that it’s now coming back, bigger and better, this week.The second annual Prince George’s Film Festival returns Wednesday, Sept. 27, through Sunday, Oct. 1. Marketing director Kisha Mason told WTOP it’s an opportunity to get familiar wit...

Coach McVay bemoans ‘self-inflicted wounds’ in Los Angeles Rams 19-16 loss to the Cincinnati Bengals

Published Sat, 01 Feb 2025 00:00:40 GMT

CINCINNATI (AP) — Getting into the end zone seemed tougher for the Los Angeles Rams when it mattered most on Monday night.The Rams suffered a 19-16 loss to the Bengals in their first regular-season rematch of the Super Bowl after the 2021 season. While the Aaron Donald-led defense kept Cincinnati without a touchdown in the first half, the Rams’ offense behind a young, banged up offensive line couldn’t capitalize.“I think the biggest thing for us tonight was missed opportunities early in the game in the red zone,” quarterback Matthew Stafford said. “If we can come away with some sevens there it’s probably a little bit of a different game later on.” The Rams (1-2) were 1-of-4 in their red zone trips. Their lone touchdown came in the final two minutes of the game when Tutu Atwell went in from the 1-yard line to close the deficit to three points, but the ensuing onside kick was unsuccessful.Stafford got Los Angeles off to a good start going 2 for 2 to begin the game and Atwe...